Survivin overexpression in head and neck squamous cell carcinomas as a new therapeutic target

被引：27

作者：

Frassanito, M. A. ^{[1
]}

Saltarella, I. ^{[2
]}

Vinella, A. ^{[1
]}

Lo Muzio, L. ^{[3
]}

Pannone, G. ^{[3
]}

Fumarulo, R. ^{[1
]}

Vacca, A. ^{[2
]}

Mariggio, M. A. ^{[1
]}

机构：

[1] Univ Bari Aldo Moro, Unit Gen Pathol, Dept Biomed Sci & Human Oncol, Piazza G Cesare 11, I-70124 Bari, Italy

[2] Univ Bari Aldo Moro, Unit Internal Med & Clin Oncol, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy

[3] Univ Foggia, Dept Clin & Expt Med, I-70121 Foggia, Italy

来源：

ONCOLOGY REPORTS | 2019年 / 41卷 / 05期

关键词：

survivin; head and neck squamous cell carcinoma; apoptosis; autophagy; APOPTOSIS INHIBITOR SURVIVIN; DOWN-REGULATES SURVIVIN; GROWTH IN-VIVO; CANCER CELLS; MOLECULAR-MECHANISMS; GENE-EXPRESSION; CISPLATIN SENSITIVITY; PROMOTES APOPTOSIS; DRUG-RESISTANCE; FAMILY PROTEIN;

D O I：

10.3892/or.2019.7082

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. It has poor clinical outcome due to intrinsic or acquired drug resistance. Deregulation of both apoptosis and autophagy contributes to chemotherapy resistance and disease progression. A new member of the inhibitors of apoptosis protein (IAP) family, namely survivin, is selectively overexpressed in tumors, including HNSCC, but not in normal tissues. Thus, it is considered a tumor biomarker. Here, we reviewed survivin expression and function in tumor progression focusing on its nodal role in the regulation of cell apoptosis and autophagy. Based on literature data, survivin targeting may be envisaged as a novel therapeutic strategy.

引用

页码：2615 / 2624

页数：10