The Promises and Pitfalls of Genoeconomics

被引：114
|
作者：
Benjamin, Daniel J. [1 ,2 ]
Cesarini, David [3 ,4 ]
Chabris, Christopher F. [5 ]
Glaeser, Edward L. [2 ,6 ]
Laibson, David I. [2 ,6 ]
Gudnason, Vilmundur [7 ]
Harris, Tamara B. [8 ]
Launer, Lenore J. [8 ]
Purcell, Shaun [9 ]
Smith, Albert Vernon [7 ]
Johannesson, Magnus [10 ]
Magnusson, Patrik K. E. [11 ]
Beauchamp, Jonathan P. [12 ]
Christakis, Nicholas A. [13 ,14 ]
Atwood, Craig S. [15 ]
Hebert, Benjamin [6 ]
Freese, Jeremy [16 ]
Hauser, Robert M. [17 ]
Hauser, Taissa S. [17 ]
Grankvist, Alexander [11 ]
Hultman, Christina M. [11 ]
Lichtenstein, Paul [11 ]
机构：
[1] Cornell Univ, Dept Econ, Ithaca, NY 14853 USA
[2] Natl Bur Econ Res, Cambridge, MA 02138 USA
[3] NYU, Ctr Expt Social Sci, New York, NY 10012 USA
[4] NYU, Dept Econ, New York, NY 10012 USA
[5] Union Coll, Dept Psychol, Schenectady, NY 12308 USA
[6] Harvard Univ, Dept Econ, Cambridge, MA 02138 USA
[7] Iceland Heart Assoc, IS-201 Kopavogur, Iceland
[8] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
[9] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
[10] Stockholm Sch Econ, Dept Econ, SE-11383 Stockholm, Sweden
[11] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden
[12] McKinsey Consulting, Montreal, PQ H3B 4W8, Canada
[13] Harvard Univ, Dept Sociol, Cambridge, MA 02138 USA
[14] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA
[15] Univ Wisconsin, Dept Med, Madison, WI 53705 USA
[16] Northwestern Univ, Dept Sociol, Evanston, IL 60208 USA
[17] Univ Wisconsin, Dept Sociol, Madison, WI 53706 USA
来源：
ANNUAL REVIEW OF ECONOMICS, VOL 4 | 2012年 / 4卷
关键词：
genetics; heritability; GWAS; GENOME-WIDE ASSOCIATION; SEMIALDEHYDE DEHYDROGENASE-DEFICIENCY; BY-ENVIRONMENT INTERACTION; COMMON SNPS EXPLAIN; CANDIDATE GENE; FUNCTIONAL POLYMORPHISM; PERSONALITY DIMENSIONS; MONOAMINE-OXIDASE; DICTATOR GAME; FTO GENE;
D O I：
10.1146/annurev-economics-080511-110939
中图分类号：
F [经济];
学科分类号：
02 ;
摘要：
This article reviews existing research at the intersection of genetics and economics, presents some new findings that illustrate the state of genoeconomics research, and surveys the prospects of this emerging field. Twin studies suggest that economic outcomes and preferences, once corrected for measurement error, appear to be about as heritable as many medical conditions and personality traits. Consistent with this pattern, we present new evidence on the heritability of permanent income and wealth. Turning to genetic association studies, we survey the main ways that the direct measurement of genetic variation across individuals is likely to contribute to economics, and we outline the challenges that have slowed progress in making these contributions. The most urgent problem facing researchers in this field is that most existing efforts to find associations between genetic variation and economic behavior are based on samples that are too small to ensure adequate statistical power. This has led to many false positives in the literature. We suggest a number of possible strategies to improve and remedy this problem: (a) pooling data sets, (b) using statistical techniques that exploit the greater information content of many genes considered jointly, and (c) focusing on economically relevant traits that are most proximate to known biological mechanisms.
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页码：627 / +
页数：37
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