The Ubiquitin Proteasome System as a Potential Target for the Treatment of Neurodegenerative Diseases

被引：25

作者：

Ying, Zheng ^{[1
]}

Wang, Hongfeng ^{[1
]}

Wang, Guanghui ^{[1
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, Lab Mol Neuropathol, Suzhou 215123, Jiangsu, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 18期

关键词：

Ubiquitin-proteasome system; deubiquitination; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; HELICAL-FILAMENT-TAU; AMYOTROPHIC-LATERAL-SCLEROSIS; SPORADIC PARKINSONS-DISEASE; AMYLOID BETA-PROTEIN; LINKED MUTANT SOD1; MOTOR-NEURON DEATH; ALPHA-SYNUCLEIN; ALZHEIMER-DISEASE; CU; ZN-SUPEROXIDE DISMUTASE; UBIQUITYLATED INCLUSIONS;

D O I：

10.2174/1381612811319180013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neurodegenerative diseases are severe disorders characterized by progressive neurodegeneration in specific brain regions. The ubiquitin-proteasome system (UPS) is closely linked to neurodegenerative disease. In most cases, UPS impairment and dysregulation of the UPS components are frequently observed. Moreover, toxin-induced neurodegeneration produces neuronal cell death accompanied by decreased UPS function. These studies suggest an involvement of the UPS in these diseases. In this review, we summarize the changes to UPS components in neurodegenerative diseases and the association between the UPS and disease pathology. Dysfunction of the UPS results in the abnormal accumulation of proteins; thus, the UPS plays a critical role in disease pathogenesis. Drugs targeting specific components of the UPS may provide promising strategies for disease treatment.

引用

页码：3305 / 3314

页数：10

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