Biodegradable organic acid-crosslinked alkali-treated gelatins with anti-thrombogenic and endothelialization properties

被引：0
|
作者：
Inoue, Motoki [1 ]
Sasaki, Makoto [1 ,2 ]
Taguchi, Tetsushi [1 ,2 ]
机构：
[1] Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton MANA, Biomat Unit, Nanolife Field, Tsukuba, Ibaraki 3050044, Japan
[2] Univ Tsukuba, Grad Sch Pure & Appl Sci, Tsukuba, Ibaraki 3058577, Japan
来源：
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS | 2012年 / 13卷 / 06期
基金：
日本学术振兴会;
关键词：
gelatin; organic acid; anti-thrombogenic properties; endothelialization; biodegradability; blood-contacting material; IN-VITRO; TISSUE ADHESIVE; BONDING STRENGTH; BEHAVIOR; BLOOD; BIOMATERIALS; POLYMERS; CHITOSAN; GROWTH; FILMS;
D O I：
10.1088/1468-6996/13/6/064215
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Gelatins were crosslinked with organic acids and treated with alkali to impart to them endothelialization and anti-thrombogenic properties. These matrices were characterized by biochemical and physicochemical techniques. The amounts of residual amino groups in the matrices decreased with increasing crosslinker concentration. The matrices with the highest crosslinking densities showed excellent endothelial cell adhesion and proliferation. In addition, the adhesion of platelets and formation of fibrin networks on the matrices were suppressed with increasing crosslinker concentration. The matrices also exhibited excellent biodegradability, and the degradation rate decreased with increasing crosslinking density. All the organic acid-crosslinked alkali-treated gelatins showed excellent anti-thrombogenic and endothelialization properties, superior to those of glutaraldehyde-crosslinked alkali-treated gelatins.
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页数：9
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