Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

被引：1

作者：

Pratt, Caroline Quinn ^{[1
]}

Zhu, Yuwei ^{[2
]}

Grijalva, Carlos G. ^{[3
]}

Wunderink, Richard G. ^{[4
]}

Courtney, D. Mark ^{[5
]}

Waterer, Grant ^{[4
,6
]}

Levine, Min Z. ^{[7
]}

Jefferson, Stacie ^{[7
]}

Self, Wesley H. ^{[8
]}

Williams, Derek J. ^{[9
]}

Finelli, Lynn ^{[7
]}

Bramley, Anna M. ^{[7
]}

Edwards, Kathryn M. ^{[10
]}

Jain, Seema ^{[7
]}

Anderson, Evan J. ^{[11
,12
]}

机构：

[1] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[2] Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Sch Med, Dept Hlth Policy, Nashville, TN 37212 USA

[4] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

[5] Northwestern Univ, Dept Emergency Med, Feinberg Sch Med, Chicago, IL 60611 USA

[6] Univ Western Australia, Perth, WA, Australia

[7] Ctr Dis Control & Prevent, Atlanta, GA USA

[8] Vanderbilt Univ, Sch Med, Dept Emergency Med, Nashville, TN 37212 USA

[9] Vanderbilt Univ, Sch Med, Dept Pediat, Div Hosp Med,Monroe Carell Jr Childrens Hosp, Nashville, TN 37212 USA

[10] Vanderbilt Univ, Sch Med, Dept Pediat, Monroe Carell Jr Childrens Hosp,Div Infect Dis, Nashville, TN 37212 USA

[11] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USA

[12] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30322 USA

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2019年 / 13卷 / 02期

关键词：

IMMUNE-RESPONSE; IMMUNOGENICITY; EFFICACY; SAFETY;

D O I：

10.1111/irv.12622

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (>= 1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (>= 4-fold HAI rise) to >= 1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

引用

页码：208 / 212

页数：5

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