Development of a novel and direct peptide Helicon™ inhibitor of ß-catenin-TCF interaction with in vivo validation of transcriptional modulation and anti-tumor activity

被引：0

作者：

Si, Yaguang ^{[1
]}

White, Brian ^{[1
]}

Cappucci, Sarah ^{[1
]}

Ramirez, Jessica ^{[1
]}

Ponthier, Charles ^{[1
]}

Visness, Erica ^{[1
]}

Ling, Kevin ^{[1
]}

Du, Peicheng ^{[1
]}

Choi, Minjung ^{[1
]}

Thomson, Ty ^{[1
]}

Alfaro-Lopez, Josue ^{[1
]}

Beerepoot, Pieter ^{[1
]}

Agarwal, Sorabh ^{[1
]}

Ortet, Paula ^{[1
]}

Lech, Miroslaw ^{[1
]}

Li, Zhi ^{[2
]}

Olokpa, Voke ^{[3
]}

Jewett, Ivan ^{[4
]}

La, Daniel ^{[5
]}

Yu, Lihua ^{[1
]}

McGee, John ^{[1
]}

Tremblay, Martin ^{[1
]}

Hurov, Jonathan ^{[1
]}

Verdine, Greg ^{[1
]}

机构：

[1] FogPharma, Cambridge, MA USA

[2] Georgetown Univ, Washington, DC USA

[3] Ikena Oncol, Cambridge, MA USA

[4] Black Diamond Therapeut, Cambridge, MA USA

[5] Santi Therapeut, Cambridge, MA USA

来源：

CANCER RESEARCH | 2022年 / 82卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

345

引用

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页数：2

共 25 条

[1] Discovery of a Helicon™ peptide inhibitor of the beta-catenin-TCF interaction with in vivo activity
White, Brian H.
Si, Yaguang
Cappucci, Sarah
Li, Zhi
Ramirez, Jessica D.
Ponthier, Charles M.
Visness, Erica
Du, Peicheng
Choi, Minjung
Beerepoot, Pieter C.
Ortet, Paula C.
Jewett, Ivan T.
Alfaro-Lopez, Josue
Agarwal, Sorabh
La, Daniel
Fulgham, Aaron
Mcgee, John H.
Orford, Keith
Hurov, Jonathan B.
Tremblay, Martin R.
Verdine, Gregory L.
CANCER RESEARCH, 2023, 83 (07)
[2] Anti-tumor activity of Helicon inhibitors of B-catenin-TCF interaction in patient-derived xenograft models
Si, YaGuang
Choi, Minjung
Han, Xinwei
White, Brian
Wu, Ziyang
Visness, Erica
Beerepoot, Pieter
Jaensch, Elizabeth
Ramirez, Jessica
Ponthier, Charles
Han, Xiaogang
Ortet, Paula
Du, Peicheng
Agarwal, Sorabh
Lech, Mirek
Fulgham, Aaron
Cappucci, Sarah
Li, Zhi
Mcgee, John
Yu, Lihua
Tremblay, Martin
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[3] Preclinical development of a novel oral multitargeted kinase inhibitor with potent in vivo anti-tumor activity
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[4] Discovery of a novel HDM2 inhibitor with potent in vivo anti-tumor activity
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[5] Identification of a novel GLUT1 inhibitor with in vitro and in vivo anti-tumor activity
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He, Chuanjie
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Li, Jiao
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[6] Anti-tumor effects of a novel peptide type Wnt/β-catenin pathway inhibitor against acute myelogeneous leukemia
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[7] Anti-tumor activity of a novel EGFR tyrosine kinase inhibitor against human NSCLC in vitro and in vivo
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[8] Marchantin C, a novel microtubule inhibitor from liverwort with anti-tumor activity both in vivo and in vitro
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[10] SY-7021, a novel DNA-PK inhibitor, exhibits significant anti-tumor activity in vitro and in vivo
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