STRESS INDUCES EQUIVALENT REMODELING OF HIPPOCAMPAL SPINE SYNAPSES IN A SIMULATED POSTPARTUM ENVIRONMENT AND IN A FEMALE RAT MODEL OF MAJOR DEPRESSION

被引：20

作者：

Baka, Judith ^{[1
]}

Csakvari, Eszter ^{[1
]}

Huzian, Orsolya ^{[1
]}

Dobos, Nikoletta ^{[1
]}

Siklos, Laszlo ^{[1
]}

Leranth, Csaba ^{[2
,3
]}

Maclusky, Neil J. ^{[4
]}

Duman, Ronald S. ^{[3
,5
]}

Hajszan, Tibor ^{[1
,2
]}

机构：

[1] Hungarian Acad Sci, Biol Res Ctr, Inst Biophys, Temesvari Krt 62, H-6726 Szeged, Hungary

[2] Yale Univ, Dept Obstet Gynecol & Reprod Sci, Sch Med, 333 Cedar St, New Haven, CT 06510 USA

[3] Yale Univ, Sch Med, Dept Neurosci, 333 Cedar St, New Haven, CT 06510 USA

[4] Univ Guelph, Dept Biomed Sci, Ontario Vet Coll, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada

[5] Yale Univ, Sch Med, Dept Psychiat, 34 Pk St, New Haven, CT 06508 USA

来源：

NEUROSCIENCE | 2017年 / 343卷

基金：

匈牙利科学研究基金会;

关键词：

postpartum depression; estradiol; progesterone; stress; plasticity; electron microscopy; GESTATIONAL STRESS; MOOD DISORDERS; CELL-PROLIFERATION; ANTIDEPRESSANT TREATMENT; FLUOXETINE TREATMENT; OVARIECTOMIZED RATS; RESTRAINT STRESS; GONADAL-STEROIDS; MENTAL-ILLNESS; MATERNAL-CARE;

D O I：

10.1016/j.neuroscience.2016.12.021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stress and withdrawal of female reproductive hormones are known risk factors of postpartum depression. Although both of these factors are capable of powerfully modulating neuronal plasticity, there is no direct electron microscopic evidence of hippocampal spine synapse remodeling in postpartum depression. To address this issue, hormonal conditions of pregnancy and postpartum period were simulated in ovariectomized adult female Sprague Dawley rats (n = 76). The number of hippocampal spine synapses and the depressive behavior of rats in an active escape task were investigated in untreated control, hormone-withdrawn 'postpartum', simulated proestrus, and hormone-treated 'postpartum' animals. After 'postpartum' withdrawal of gonadal steroids, inescapable stress caused a loss of hippocampal spine synapses, which was related to poor escape performance in hormone-withdrawn 'postpartum' females. These responses were equivalent with the changes observed in untreated controls that is an established animal model of major depression. Maintaining proestrus levels of ovarian hormones during 'postpartum' stress exposure did not affect synaptic and behavioral responses to inescapable stress in simulated proestrus animals. By contrast, maintaining pregnancy levels of estradiol and progesterone during 'postpartum' stress exposure completely prevented the stress-induced loss of hippocampal spine synapses, which was associated with improved escape performance in hormone-treated 'postpartum' females. This protective effect appears to be mediated by a muted stress response as measured by serum corticosterone concentrations. In line with our emerging 'synaptogenic hypothesis' of depression, the loss of hippocampal spine synapses may be a novel perspective both in the pathomechanism and in the clinical management of postpartum affective illness. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：384 / 397

页数：14

共 1 条

[1] Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression
Hajszan, Tibor
Dow, Antonia
Warner-Schmidt, Jennifer L.
Szigeti-Buck, Klara
Sallam, Nermin L.
Parducz, Arpad
Leranth, Csaba
Duman, Ronald S.
BIOLOGICAL PSYCHIATRY, 2009, 65 (05) : 392 - 400

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