Targeting the tumor microenvironment for pancreatic ductal adenocarcinoma therapy

被引：11

作者：

Zhang, Yi-Fan ^{[1
]}

Jiang, Shu-Heng ^{[1
]}

Hu, Li-Peng ^{[1
]}

Huang, Pei-Qi ^{[1
]}

Wang, Xu ^{[1
]}

Li, Jun ^{[1
]}

Zhang, Xue-Li ^{[1
]}

Nie, Hui-Zhen ^{[1
]}

Zhang, Zhi-Gang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Jiao Tong Univ Med, Ren Ji Hosp, State Key Lab Oncogenes & Related Genes, Shanghai 200240, Peoples R China

来源：

CHINESE CLINICAL ONCOLOGY | 2019年 / 8卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Pancreatic cancer; tumor therapy; tumor microenvironment; ENHANCES CHEMOTHERAPY; NAB-PACLITAXEL; STELLATE CELLS; IMMUNE CELLS; CANCER CELLS; T-CELLS; PROLIFERATION; FIBROBLASTS; ACTIVATION; APOPTOSIS;

D O I：

10.21037/cco.2019.03.02

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is one of the most dangerous cancers, and the overall 5-year survival rate is only 8%. The microenvironment of PDAC, which promotes tumorigenesis, disease development and metastasis, consists of fibroblasts, immune cells, pancreatic stellate cells (PaSCs), adipocytes and extracellular matrix (ECM). Because the microenvironment is a part of the tumor, it is also an important target for PDAC treatment. Several therapeutic regimens targeting PDAC microenvironment factors or cells have been investigated, but the treatment effects were poor. More research on the physiological and pathological mechanisms and clinical treatment of PDAC is necessary.

引用

页数：10

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