Check Your Confidence: Size Really Does Matter

被引:12
|
作者
Carlson, Heather A. [1 ]
机构
[1] Univ Michigan, Coll Pharm, Dept Med Chem, Ann Arbor, MI 48109 USA
关键词
CSAR BENCHMARK EXERCISE;
D O I
10.1021/ci4004249
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Heather A. Carlson describes the influence of many factors on linear regression and highlights the limits that they impose. A simple least-squares linear regression starts with a fit line that must intersect the point, the average calculated and experimental values. The fit is then dictated by finding a slope that minimizes the squared distances in the y direction between the data points and the fit line. A tighter correlation means better agreement between the data points and the fit line; therefore, there are smaller residuals and a tighter distribution of those residuals around the value zero. A tighter distribution means that there is a smaller standard deviation of the distribution of the residuals for the data points and a higher R. Experimental error can be incorporated as error bars in the y direction if there is a need to address some difference in uncertainty between different data points. This simply calls for a weighted linear regression.
引用
收藏
页码:1837 / 1841
页数:5
相关论文
共 50 条
  • [1] Does your result checker really check?
    Guo, L
    Mukhopadhyay, S
    Cukic, B
    [J]. 2004 INTERNATIONAL CONFERENCE ON DEPENDABLE SYSTEMS AND NETWORKS, PROCEEDINGS, 2004, : 399 - 404
  • [2] Size does really matter
    Kilbourne, Sarah
    Krupnick, Alexander Sasha
    [J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2018, 155 (04): : 1880 - 1881
  • [3] Does size really matter?
    Simon Frantz
    Paul Smaglik
    [J]. Nature Reviews Drug Discovery, 2003, 2 : 413 - 413
  • [4] Does Size Really Matter?
    Hutchinson, Mark R.
    [J]. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2017, 99 (12):
  • [5] Does size really matter?
    Marois, Guillaume
    [J]. CANADIAN STUDIES IN POPULATION, 2018, 45 (1-2) : 79 - 83
  • [6] Does Size Really Matter?
    Coelho-Prabhu, Nayantara
    Kane, Sunanda
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2021, 116 (01): : 84 - 85
  • [7] Does size really matter?
    Vardon, Sue
    [J]. AUSTRALIAN JOURNAL OF PUBLIC ADMINISTRATION, 2007, 66 (03) : 261 - 274
  • [8] Size really does matter!
    Czap, Al
    [J]. ALTERNATIVE MEDICINE REVIEW, 2006, 11 (04) : 267 - 268
  • [9] Does Size Really Matter?
    Rubin, Marc S.
    [J]. DISEASES OF THE COLON & RECTUM, 2017, 60 (09) : 877 - 878
  • [10] Does size really matter?
    Frantz, S
    Smaglik, P
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) : 413 - 413