Determination of the starting dose in the first-in-human clinical trial of ERY974, a novel T cell-redirecting bispecific antibody targeting glypican-3, from MABEL and NOAEL approaches

被引：0

作者：

Sano, Y. ^{[1
]}

Komatsu, S. I. ^{[1
]}

Frings, W. ^{[1
]}

Kaneko, A. ^{[1
]}

Takahiro, I. ^{[1
]}

Kayukawa, Y. ^{[1
]}

Ono, N. ^{[1
]}

Sakata, K. ^{[1
]}

Fujii, T. ^{[1
]}

Miyazaki, Y. ^{[1
]}

Kinoshita, Y. ^{[1
]}

Azuma, Y. ^{[1
]}

Tsunenari, T. ^{[1
]}

Kishishita, S. ^{[1
]}

Endo, M. ^{[1
]}

Nezu, J. ^{[1
]}

机构：

[1] Chugai Pharmaceut Co Ltd, Div Res, Kamakura, Kanagawa, Japan

来源：

EUROPEAN JOURNAL OF CANCER | 2018年 / 103卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

322 (PB-08

引用

页码：E107 / E108

页数：2

共 11 条

[1] Determination of starting dose of the T cell-redirecting bispecific antibody ERY974 targeting glypican-3 in first-in-human clinical trial
Shun-ichiro Komatsu
Yoko Kayukawa
Yoko Miyazaki
Akihisa Kaneko
Hisashi Ikegami
Takahiro Ishiguro
Mikiko Nakamura
Werner Frings
Natsuki Ono
Kiyoaki Sakata
Toshihiko Fujii
Shohei Kishishita
Takehisa Kitazawa
Mika Endo
Yuji Sano
Scientific Reports, 12
[2] Determination of starting dose of the T cell-redirecting bispecific antibody ERY974 targeting glypican-3 in first-in-human clinical trial
Komatsu, Shun-ichiro
Kayukawa, Yoko
Miyazaki, Yoko
Kaneko, Akihisa
Ikegami, Hisashi
Ishiguro, Takahiro
Nakamura, Mikiko
Frings, Werner
Ono, Natsuki
Sakata, Kiyoaki
Fujii, Toshihiko
Kishishita, Shohei
Kitazawa, Takehisa
Endo, Mika
Sano, Yuji
SCIENTIFIC REPORTS, 2022, 12 (01)
[3] Impact of regulatory T cells on cellular cytotoxicity induced by ERY974, a novel T cell-redirecting bispecific antibody targeting glypican-3
Sonobe, Y.
Miyazaki, Y.
Sano, Y.
Kinoshita, Y.
Azuma, Y.
Tsunenari, T.
Ishiguro, T.
Kishishita, S.
Endo, M.
Nezu, J.
EUROPEAN JOURNAL OF CANCER, 2018, 103 : E55 - E55
[4] ERY974, a novel T cell-redirecting bispecific antibody targeting glypican-3, shows antitumor activity in gastric cancer patient-derived xenograft models with varying glypican-3 expression
Yumiko, Azuma
Sano, Yuji
Tsunenari, Toshiaki
Kinoshita, Yasuko
Miyazaki, Yoko
Shinozuka, Junko
Fujii, Etsuko
Kato, Atsuhiko
Ishiguro, Takahiro
Kishishita, Shohei
Nezu, Junichi
Kawabe, Yoshiki
Endo, Mika
CANCER RESEARCH, 2018, 78 (13)
[5] Pharmacological Characterization of Anti-Glypican 3/CD3 Bispecific T Cell-Redirecting Antibody ERY974
Kishishita, Shohei
CANCER SCIENCE, 2018, 109 : 332 - 332
[6] Differential exhaustion on cytokine release (DECREASE) by ERY974, a novel T-cell-redirecting antibody targeting glypican-3: A new type of T-cell exhaustion
Hoshino, Mayumi
Sano, Yuji
Kinoshita, Yasuko
Azuma, Yumiko
Tsunenari, Toshiaki
Kayukawa, Yoko
Noguchi, Mizuho
Ishiguro, Takahiro
Kishishita, Shohei
Sawada, Noriaki
Endo, Mika
Nezu, Junichi
CANCER RESEARCH, 2019, 79 (13)
[7] First-in-class T cell-redirecting bispecific antibody targeting glypican-3: a highly tumor-selective antigen
Ishiguro, Takahiro
Kinoshita, Yasuko
Sano, Yuji
Azuma, Yumiko
Tsunenari, Toshiaki
Ono, Natsuki
Kayukawa, Yoko
Kamata-Sakurai, Mika
Shiraiwa, Hirotake
Kaneko, Akihisa
Frings, Werner
Komatsu, Shunichiro
Nezu, Junichi
Endo, Mika
CANCER RESEARCH, 2016, 76
[8] Combining ERY974, a novel Tcell-redirecting bispecific antibody targeting glypican-3, with chemotherapy profoundly improved antitumor efficacy over its monotherapy in xenograft model
Sano, Yuji
Azuma, Yumiko
Tsunenari, Toshiaki
Kinoshita, Yasuko
Kayukawa, Yoko
Mutoh, Hironori
Miyazaki, Yoko
Ishiguro, Takahiro
Kishishita, Shohei
Kawabe, Yoshiki
Endo, Mika
CANCER RESEARCH, 2017, 77
[9] Preclinical PET imaging of bispecific antibody ERY974 targeting CD3 and glypican 3 reveals that tumor uptake correlates to T cell infiltrate
Waaijer, Stijn J. H.
Giesen, Danique
Ishiguro, Takahiro
Sano, Yuji
Sugaya, Naofumi
Schroder, Carolina P.
de Vries, Elisabeth G. E.
Lub-de Hooge, Marjolijn N.
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)
[10] Anti-GPC3 TRAB, a first-in-class T cell-redirecting bispecific antibody targeting glypican-3 with potent in vitro and in vivo antitumor efficacy against solid tumors
Kinoshita, Yasuko
Ishiguro, Takahiro
Sano, Yuji
Azuma, Yumiko
Tsunenari, Toshiaki
Ono, Natsuki
Kayukawa, Yoko
Ueda, Otoya
Wada, Naoko A.
Hino, Hiroshi
Jishage, Koichi
Shiraiwa, Hirotake
Kamata-Sakurai, Mika
Nezu, Junichi
Endo, Mika
CANCER RESEARCH, 2016, 76

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