Effect of paracetamol use on the modification of the development of asthma by reactive oxygen species genes

被引:28
|
作者
Kang, Sung Han [1 ]
Jung, Young-Ho [1 ,2 ]
Kim, Hyung Young [1 ,2 ]
Seo, Ju-Hee [1 ,2 ]
Lee, Jung-Yong [1 ,2 ]
Kwon, Ji-Won [3 ]
Kim, Byoung-Ju [4 ]
Kim, Hyo Bin [5 ]
Lee, So Yeon [6 ]
Jang, Gwang Cheon [7 ]
Song, Dae Jin [8 ]
Kim, Woo-Kyung [9 ]
Shim, Jung Yeon [10 ]
Kim, Jae-Hee [11 ]
Kang, Mi-Jin [12 ]
Yu, Ho-Sung [12 ]
Yu, Jinho [1 ]
Hong, Soo-Jong [1 ,2 ]
机构
[1] Univ Ulsan, Coll Med, Childhood Asthma Atopy Ctr, Dept Pediat,Asan Med Ctr, Seoul 138736, South Korea
[2] Univ Ulsan, Coll Med, Res Ctr Standardizat Allerg Dis, Dept Pediat,Asan Med Ctr, Seoul 138736, South Korea
[3] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Pediat, Songnam, South Korea
[4] Inje Univ, Coll Med, Hae Undae Paik Hosp, Dept Pediat, Pusan, South Korea
[5] Inje Univ, Coll Med, Sanggye Paik Hosp, Dept Pediat, Pusan, South Korea
[6] Hallym Univ, Sacred Heart Hosp, Dept Pediat, Anyang, South Korea
[7] Ilsan Hosp, Natl Hlth Insurance Corp, Dept Pediat, Goyang, South Korea
[8] Korea Univ, Guro Hosp, Dept Pediat, Seoul, South Korea
[9] Inje Univ, Coll Med, Seoul Paik Hosp, Dept Pediat, Seoul, South Korea
[10] Sungkyunkwan Univ, Coll Med, Kangbuk Samsung Hosp, Dept Pediat, Seoul, South Korea
[11] Univ Ulsan, Coll Med, Seoul 138736, South Korea
[12] Asan Med Ctr, Asan Inst Life Sci, Seoul, South Korea
关键词
EARLY-LIFE; ACETAMINOPHEN USE; RISK; CHILDHOOD; CHILDREN; ASSOCIATION; GLUTATHIONE; PREVALENCE; EXPOSURE; ASPIRIN;
D O I
10.1016/j.anai.2013.03.008
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Recent studies have identified an increase in the prevalence of asthma associated with paracetamol use. Objective: To identify the relationship among asthma, biomarkers, genes, and paracetamol use in preschool children. Methods: We undertook a population-based, cross-sectional survey of 933 preschool children. Asthma status was classified according to medical history and asthmatic symptoms. History of paracetamol use in infancy was recorded. Impulse oscillometry, blood tests for eosinophils and total IgE, and genotyping of NAT2, Nrf2, and GSTP1 polymorphisms by TaqMan assay were conducted. Result: Paracetamol use in infancy was associated with an increased risk of treatment for asthma within the previous 12 months. Paracetamol use together with a family history of asthma increased the risk of asthma diagnosis ever, current asthma, and treatment for asthma within the previous 12 months. Gene polymorphisms in NAT2 (rs4271002), Nrf2 (rd6726395), and GSTP1 (rd1695) increased the risk of treatment for asthma within the last 12 months. Eosinophils were significantly elevated in the group with paracetamol use and a family history of asthma; however, the serum total IgE level and IOS did not show any significant difference. Conclusion: Paracetamol use in infancy was significantly associated with increased risk of asthma. The association is more significant in genetically susceptible children, related to antioxidant genes, and the effect may be mediated by eosinophilic inflammation. (c) 2013 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:364 / +
页数:7
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