Dynamical Analysis of a Delayed HIV Virus Dynamic Model with Cell-to-Cell Transmission and Apoptosis of Bystander Cells

被引：3
|
作者：
Zhang, Tongqian [1 ,2 ,3 ]
Wang, Junling [1 ]
Song, Yi [1 ]
Jiang, Zhichao [4 ]
机构：
[1] Shandong Univ Sci & Technol, Coll Math & Syst Sci, Qingdao 266590, Peoples R China
[2] Shandong Univ Sci & Technol, State Key Lab Min Disaster Prevent & Control, Qingdao 266590, Peoples R China
[3] Shandong Univ Sci & Technol, Minist Sci & Technol, Qingdao 266590, Peoples R China
[4] North China Inst Aerosp Engn, Sch Liberal Arts & Sci, Langfang 065000, Peoples R China
来源：
COMPLEXITY | 2020年 / 2020卷
基金：
中国国家自然科学基金;
关键词：
CTL IMMUNE-RESPONSE; MATHEMATICAL-ANALYSIS; INFECTION MODEL; GLOBAL STABILITY; VIRAL DYNAMICS; SPREAD; TIME; CD4(+); GROWTH;
D O I：
10.1155/2020/2313102
中图分类号：
O1 [数学];
学科分类号：
0701 ; 070101 ;
摘要：
In this paper, a delayed viral dynamical model that considers two different transmission methods of the virus and apoptosis of bystander cells is proposed and investigated. The basic reproductive number R-0 of the model is derived. Based on the basic reproductive number, we prove that the disease-free equilibrium E-0 is globally asymptotically stable for R-0<1 by constructing suitable Lyapunov functional. For R-0>1, by regarding the time delay as bifurcation parameter, the existence of local Hopf bifurcation is investigated. The results show that time delay can change the stability of endemic equilibrium and cause periodic oscillations. Finally, we give some numerical simulations to illustrate the theoretical findings.
引用
收藏
页数：12
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