Expression of a CD44 variant containing exons 8 to 10 is a useful independent factor for the prediction of prognosis in colorectal cancer patients

被引:90
|
作者
Yamaguchi, A [1 ]
Urano, T [1 ]
Goi, T [1 ]
Saito, M [1 ]
Takeuchi, K [1 ]
Hirose, K [1 ]
Nakagawara, G [1 ]
Shiku, H [1 ]
Furukawa, K [1 ]
机构
[1] NAGASAKI UNIV,SCH MED,DEPT ONCOL,NAGASAKI 852,JAPAN
关键词
D O I
10.1200/JCO.1996.14.4.1122
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To determine the expression of the CD44 variant containing a variant exon 8 to 10 product (CD44v8-10) in colorectal cancer and to evaluate its prognostic value. Materials and Methods: CD44v8-10 was studied in resected tumors and normal mucosae obtained from 215 colorectal cancer patients (118 colon cancer and 97 rectal cancer). The expression of CD44v8-10 was analyzed immunohistochemically using the anti-CD44v8-10 monoclonal antibody (mAb) 44-1V. Results: One hundred of 215 cancer tissues expressed CD44v8-10. Positive staining was intense mainly on the cell membranes. There was no significant correlation between expression of CD44v8-10 and histologic type, primary tumor, lymphatic invasion, venous invasion, or peritoneal invasion. There were significant correlations between CD44v8-10 immunoreactivity and both lymph node and hematogenous metastasis. Patients with CD44v8-10-positive tumors had a greater relative risk of death compared with those whose tumors were CD44v8-10-negative. Among 169 patients who underwent curative resection, CD44v8-10 expression correlated with a high recurrence rate. The 5- and 10-year survival rates were 90.3% of patients with CD44v8-10-negative tumors, and 72.1% and 58.0% of those with CD44v8-10-positive tumors, respectively; these differences between the two groups of patients were significant (P < .01). In multivariate analysis using the Cox regression model, CD44v8-10 expression emerged as an independent prognostic indicator. Conclusion: The results suggest that CD44v8-10 plays a role in metastasis of colorectal cancer, and that CD44v8-10 expression may be a biologic marker of prognostic significance. (C) 1996 by American Society of Clinical Oncology.
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页码:1122 / 1127
页数:6
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