Carbohydrate-based vaccines for oncotherapy

被引：69

作者：

Wei, Meng-Man ^{[1
]}

Wang, Yong-Shi ^{[1
]}

Ye, Xin-Shan ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, XueYuan Rd 38, Beijing 100191, Peoples R China

来源：

MEDICINAL RESEARCH REVIEWS | 2018年 / 38卷 / 03期

基金：

中国国家自然科学基金;

关键词：

cancer vaccine; drug discovery; immunotherapy; review; tumor-associated carbohydrate antigen; KEYHOLE LIMPET HEMOCYANIN; SYNTHETIC ANTITUMOR VACCINES; ACTIVE SPECIFIC IMMUNOTHERAPY; TUMOR-ASSOCIATED ANTIGEN; MONOPHOSPHORYL-LIPID-A; BREAST-CANCER PATIENTS; CLUSTERED TN-ANTIGEN; BACTERIOPHAGE Q-BETA; SIALYL-LEWIS-X; IMMUNOLOGICAL EVALUATION;

D O I：

10.1002/med.21493

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cancer is still one of the most serious threats to human worldwide. Aberrant patterns of glycosylation on the surface of cancer cells, which are correlated with various cancer development stages, can differentiate the abnormal tissues from the healthy ones. Therefore, tumor-associated carbohydrate antigens (TACAs) represent the desired targets for cancer immunotherapy. However, these carbohydrate antigens may not able to evoke powerful immune response to combat with cancer for their poor immunogenicity and immunotolerance. Different approaches have been developed to address these problems. In this review, we want to summarize the latest advances in TACAs based anticancer vaccines.

引用

页码：1003 / 1026

页数：24

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