Protective effect of reamberin on functional activity of mitochondria during skin ischemia

被引:0
|
作者
Galenko-Yaroshevskii, VP [1 ]
Agadzhanova, AV
Fedorovich, KO
Lapina, NV
Gorelashvili, AS
Berberashvili, TM
Sukoyan, GV
机构
[1] Russian Acad Med Sci, Krasnodar Branch, So Bur, Moscow 109801, Russia
[2] NV Krasanov Republ Res Ctr Med Biophys & Implemen, Tbilisi, Georgia
关键词
skin ischemia; mitochondria; energotropic effect; reamberin; antioxidant protection system;
D O I
10.1007/s10517-005-0513-x
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Reamberin in a dose of 25 mg/kg (succinate concentration) was injected intravenously for 3 days starting from the 1st hour after skin ischemia modeling. This treatment decreased activities of lactate dehydrogenase, aspartate transaminase, and creatine phosphokinase in skin homogenates by 1.6 times, 19%, and 51.3%, respectively. The index of cytolysis decreased by 18%. Reamberin had an energotropic effect, which manifested in an increase in the total ATP content and concentration of creatine phosphate (by 16 and 10%, respectively). After administration of Reamberin, activity of the succinate-ubiquinone reductase system increased by 17%. Under these conditions succinate dehydrogenase activity exceeded the normal by 21%. Reamberin had no effect on the mitochondrial NADH-ubiquinone reductase system in dermal cells during skin ischemia. Superoxide dismutase activity in the area of necrosis increased to the control level on day 3 of treatment with Reamberin. Activities of catalase and glutathione peroxidase increased by 13 and 19%, respectively. Our results indicate that the course of intravenous treatment with Reamberin for 3 days contributes to an increase in reserve capacities of the antioxidant protection system and produces a protective effect during skin ischemia.
引用
收藏
页码:435 / 438
页数:4
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