Electrocatalytic activity of activated niclosamide on multi-walled carbon nanotubes glassy carbon electrode toward NADH oxidation

被引:5
|
作者
Lopes, Cleylton Bezerra [1 ,2 ,5 ]
dos Santos Silva, Francisco de Assis [3 ,5 ]
Lima, Phabyanno Rodrigues [2 ,5 ]
de Freitas, Johnnatan Duarte [2 ]
Sousa, Jonas dos Santos [2 ]
Kubota, Lauro Tatsuo [4 ,5 ]
Fonseca Goulart, Marilia Oliveira [1 ,5 ]
机构
[1] Univ Fed Alagoas UFAL, IQB, BR-57072970 Maceio, AL, Brazil
[2] IFAL, Inst Fed Educ Ciencia & Tecnol Alagoas, BR-57020600 Maceio, AL, Brazil
[3] IFG, Inst Fed Educ Ciencia & Tecnol Goias, BR-76400000 Uruacu, Go, Brazil
[4] Univ Estadual Campinas, Inst Quim, BR-13084971 Campinas, SP, Brazil
[5] Univ Estadual Campinas, Inst Nacl Ciencia & Tecnol Bioanalit, BR-13084971 Campinas, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
Sensors; Chemically modified electrode; Niclosamide; Mediators; MWCNT; NADH; NICOTINAMIDE ADENINE-DINUCLEOTIDE; VOLTAMMETRIC DETERMINATION; PASTE ELECTRODE; COMPOSITE; ACID; NANOPARTICLES; DERIVATIVES; MEDIATOR; DAMAGE;
D O I
10.1007/s10008-015-2862-3
中图分类号
O646 [电化学、电解、磁化学];
学科分类号
081704 ;
摘要
A simple and sensitive method for the electrocatalytic detection of dihydronicotinamide adenine dinucleotide (NADH) on an activated niclosamide (activatedNIC)-based modified electrode, prepared on a glassy carbon electrode modified with multi-walled carbon nanotubes (GCE/MWCNT/activatedNIC), was developed. This modified electrode shows efficient electrocatalytic oxidation activity toward NADH, at an applied potential of 0.065 V vs Ag/AgCl, with a kinetic constant, k (kin), of 1.15 x 10(4) L mol(-1) s(-1), evaluated by chronoamperometry. The sensor presents a linear response range from 10.0 up to 280.0 mu M with limits of detection and quantification and sensitivity of 3 mu M, 10 mu M, and 2.4 nA mu M-1, respectively.
引用
收藏
页码:2819 / 2829
页数:11
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