Aluminium-Catalysed Oxazolidinone Synthesis and their Conversion into Functional Non-Symmetrical Ureas

被引：17
|
作者：
Laserna, Victor [1 ]
Guo, Wusheng [1 ]
Kleij, Arjan W. [1 ,2 ]
机构：
[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain
[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 13期
关键词：
aluminium; homogeneous catalysis; N; O ligands; oxazolidinones; ureas; STEREOSELECTIVE-SYNTHESIS; PRACTICAL SYNTHESIS; ORGANIC CARBONATES; ISOCYANATES; CONVENIENT; CARBAMATE; THIOUREAS; EPOXIDES; DIOXIDE; ACCESS;
D O I：
10.1002/adsc.201500635
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient and practical aluminium-catalysed approach towards a range of functional oxazolidinones is reported. The method is based on cheap and readily available starting materials including terminal and internal (bicyclic) epoxides and phenyl carbamate. The oxazolidinones serve as highly useful synthons for the high yield preparation of non-symmetrical ureas by nucleophilic ring-opening affording the targeted urea compounds with excellent functional group diversity, high regioselectivity and isolated yields up to >99%.
引用
收藏
页码：2849 / 2854
页数：6
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