α-ketoglutarate modulates the circadian patterns of lipid peroxidation and antioxidant status during N-nitrosodiethylamine-induced hepatocarcinogenesis in rats

被引：9

作者：

Dakshayani, K. B. ^{[1
]}

Subramanian, P. ^{[1
]}

机构：

[1] Annamalai Univ, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India

来源：

JOURNAL OF MEDICINAL FOOD | 2006年 / 9卷 / 01期

关键词：

circadian rhythms; hepatocarcinogenesis; alpha-ketoglutarate; lipid peroxidation; N-nitrosodiethylamine;

D O I：

10.1089/jmf.2006.9.90

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of a-ketoglutarate (a-KG) on circadian patterns of lipid peroxides and antioxidants in N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis in rats has been studied. The circadian rhythm characteristics (acrophase, amplitude, and mesor) of thiobarbituric acid-reactive substances (TBARS), antioxidants, superoxide dismutase, catalase, glutathione peroxidase, and reduced glutathione were markedly altered in NDEA-treated rats. The delays in acrophase observed in NDEA-treated rats were brought back to near normal range by the administration of alpha-KG. An increase in mesor values of TBARS and a decrease in mesor values of antioxidants in NDEA-administered rats were reversed by alpha-KG administration. It can be concluded that alpha-KG exerts its chemopreventive effect by restoring antioxidants and their circadian rhythms.

引用

页码：90 / 97

页数：8

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