Role of group 1 CD1-restricted T cells in infectious disease

被引：30
|
作者：
Siddiqui, Sarah [1 ]
Visvabharathy, Lavanya [1 ]
Wang, Chyung-Ru [1 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Microbiol & Immunol, Chicago, IL 60611 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷
基金：
美国国家卫生研究院;
关键词：
Mycobacterium tuberculosis; CD1; antigen presentation; T cells; NKT cells; animal models; MYCOBACTERIUM-TUBERCULOSIS INFECTION; LIPID-PROTEIN INTERACTIONS; BACILLUS-CALMETTE-GUERIN; DENDRITIC CELLS; ANTIGEN PRESENTATION; NKT CELLS; CRYSTAL-STRUCTURE; GUINEA-PIG; HUMAN CD1B; ENDOPLASMIC-RETICULUM;
D O I：
10.3389/fimmu.2015.00337
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens attractive vaccine targets that could be recognized in a genetically diverse human population. Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells have been implicated to play critical roles in a variety of autoimmune and infectious diseases. In this review, we summarize current knowledge and recent discoveries on the development of group 1 CD1-restricted T cells and their function in different infection models. In particular, we focus on (1) newly identified microbial and self-lipid antigens, (2) kinetics, phenotype, and unique properties of group 1 CD1-restricted T cells during infection, and (3) the similarities of group 1 CD1-restricted T cells to the closely related group 2 CD1-restricted T cells.
引用
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页数：10
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