PD-L1 blockade: rejuvenating T cells in CLL

被引：5
|
作者：
Kater, Arnon P. [1 ]
van der Windt, Gerritje J. W. [1 ]
机构：
[1] Acad Med Ctr Amsterdam, Amsterdam, Netherlands
来源：
BLOOD | 2015年 / 126卷 / 02期
关键词：
CHRONIC LYMPHOCYTIC-LEUKEMIA; IBRUTINIB; INHIBITOR; LYMPHOMA; ITK;
D O I：
10.1182/blood-2015-05-638338
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, there are 2 articles by McClanahan et al describing T-cell defects in murine chronic lymphocytic leukemia (CLL) in the context of aging which show that therapeutic targeting of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) signaling prevents immune dysfunction and leukemia development.(1,2)
引用
收藏
页码：126 / 128
页数：5
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