A note on generalized functional linear model and its application

Motivated by a biomarker study for colorectal neoplasia, we consider generalized functional linear models where the functional predictors are measured with errors at discrete design points. Assuming that the true functional predictor and the slope function are smooth, we investigate a two-step estimating procedure where both the true functional predictor and the slope function are estimated through spline smoothing. The operating characteristics of the proposed method are derived: the usefulness of the proposed method is illustrated by a simulation study as well as data analysis for the motivating colorectal neoplasia study. (C) 2012 Elsevier B.V. All rights reserved.