Improvement of Malignant Pleural Mesothelioma Immunotherapy by Epigenetic Modulators

被引：6

作者：

Hamaidia, Malik ^{[1
,2
,3
]}

Staumont, Bernard ^{[2
]}

Duysinx, Bernard ^{[4
]}

Louis, Renaud ^{[4
]}

Willems, Luc ^{[1
,2
]}

机构：

[1] Univ Liege, AgroBioChem, Agrobio Tech, B-5030 Gembloux, Belgium

[2] Univ Liege, GIGA, B-4000 Sart Tilman Par Liege, Belgium

[3] Univ Liege, AgricultureIsLife, B-5030 Gembloux, Belgium

[4] Univ Hosp Liege, Pneumol, Sart Tilman Par Liege, Belgium

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 07期

关键词：

Cancer; Epigenetic inhibitors; Histone deacetylase; Immunotherapy; Malignant pleural mesothelioma; HISTONE DEACETYLASE INHIBITOR; REGULATORY T-CELLS; PROINFLAMMATORY GENE-EXPRESSION; TOLEROGENIC DENDRITIC CELLS; ANTITUMOR IMMUNE-RESPONSES; VALPROIC ACID; MACROPHAGE POLARIZATION; INFLAMMATORY REACTION; CYTOKINE PRODUCTION; TRICHOSTATIN-A;

D O I：

10.2174/1568026615666150825141152

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators.

引用

页码：777 / 787

页数：11

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