CRISPR/Cas: A Successful Tool for Genome Editing in Animal Models

被引：8
|
作者：
Ahmed, Bilal [1 ]
Arif, Mashaal [2 ]
Qadir, Muhammad Imran [2 ]
机构：
[1] Nanjing Med Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China
[2] Bahauddin Zakariya Univ, Inst Mol Biol & Biotechnol, Multan, Pakistan
来源：
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 2020年 / 30卷 / 03期
关键词：
zinc finger nuclease; homology-directed repair; guide RNA; GENE; CAS; MUTAGENESIS; DROSOPHILA; SEQUENCE; RNA;
D O I：
10.1615/CritRevEukaryotGeneExpr.2020028791
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
CRISPR/Cas9 is an innovative molecular tool that is utilized in advanced biological applications. This review focuses on modifying the genomes of a wide range of animals by CRISPR/Cas9 for greater usability and higher efficiency, providing an overview of the function and mechanism of this system and the utilization of this system for medicinal research. The type II CRISPR-Cas system is found in the Enterobacteriaceae bacteria family, which uses this system as a defense against invading phages and plasmids. This system can be engineered to direct its action toward a targeted site for the modification of a specific genome.
引用
收藏
页码：239 / 243
页数：5
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