Self-renewal molecular mechanisms of colorectal cancer stem cells

被引：46

作者：

Pan, Tianhui ^{[1
]}

Xu, Jinghong ^{[2
]}

Zhu, Yongliang ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Lab Gastroenterol, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pathol, Hangzhou 310009, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2017年 / 39卷 / 01期

关键词：

colorectal cancer; cancer stem cell; self-renewal; molecular mechanism; signaling pathway; molecular marker; micro-environment; TUMOR-INITIATING CELLS; WNT/BETA-CATENIN; BETA-CATENIN; SIGNALING PATHWAY; TGF-BETA; SUPPRESSOR-CELLS; INTESTINAL TUMORIGENESIS; ALDEHYDE DEHYDROGENASE; MESENCHYMAL TRANSITION; MYELOID CELLS;

D O I：

10.3892/ijmm.2016.2815

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Colorectal cancer stem cells (CCSCs) represent a small fraction of the colorectal cancer cell population that possess self-renewal and multi-lineage differentiation potential and drive tumorigenicity. Self-renewal is essential for the malignant biological behaviors of colorectal cancer stem cells. While the self-renewal molecular mechanisms of colorectal cancer stem cells are not yet fully understood, the aberrant activation of signaling pathways, such as Wnt, Notch, transforming growth factor-beta (TGF-beta)/bone morphogenetic protein (BMP) and Hedgehog-Gli (HH-GLI), specific roles mediated by cell surface markers and micro-environmental factors are involved in the regulation of self-renewal. The elucidation of the molecular mechanisms behind self-renewal may lead to the development of novel targeted interventions for the treatment of colorectal cancer.

引用

页码：9 / 20

页数：12

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