A highly enantioselective one-pot synthesis of homoallylic alcohols via tandem asymmetric allyl transfer/olefin cross metathesis

被引：20
|
作者：
Lee, CHA
Loh, TP [1 ]
机构：
[1] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 637616, Singapore
[2] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 05期
关键词：
homoallylic alcohols; allyl transfer; tandem reactions; olefin cross metathesis;
D O I：
10.1016/j.tetlet.2005.11.078
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly enantioselective one-pot synthesis of linear homoallylic alcohols with terminal ester functionality has been achieved. The reactions were controlled by ordered addition of reagents and catalysts.. ensuring complete consumption of aldehyde. The synthetic utility of this strategy has been demonstrated in a short synthesis of a low boiling point intermediate for grahamimycin A. (c) 2005 Published by Elsevier Ltd.
引用
收藏
页码：809 / 812
页数：4
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