During boiling treatment of sweet potato cultivar, "Suioh" leaves, the contents of caffeic acid (CA), 3-caffeoylquinic acid, 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid and 3,4,5-tricaffeoylquinic acid (3,4,5-triCQA) were significantly decreased. However, no significant changes of 4-caffeoylquinic acid and 3,4-dicaffeoylquinic acid were observed, and the content of 4,5-dicaffeoylquinic acid was significantly increased. When each standard solution of CA and caffeoylquinic acids (CQAs) were heated to 100 degrees C, structural isomers were generated from mono-CQAs and di-CQAs, although no significant changes were observed in CA and 3,4,5-triCQA. Therefore, differences in the contents of CA and CQAs during boiling treatment of "Suioh" leaves might be attributed to the formation of structural isomers of mono-CQAs or di-CQAs, in addition to the broth outflow of CA and CQAs in the leaves.