Bmp2 Signaling Regulates the Hepatic versus Pancreatic Fate Decision

被引:122
|
作者
Chung, Won-Suk [1 ,2 ,3 ,4 ]
Shin, Chong Hyun [1 ,2 ,3 ,4 ]
Stainier, Didier Y. R. [1 ,2 ,3 ,4 ]
机构
[1] Univ Calif San Francisco, Ctr Liver, Dept Biochem & Biophys, Program Dev Biol, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Ctr Liver, Dept Biochem & Biophys, Genet Program, San Francisco, CA 94158 USA
[3] Univ Calif San Francisco, Ctr Liver, Dept Biochem & Biophys, Program Human Genet, San Francisco, CA 94158 USA
[4] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94158 USA
关键词
D O I
10.1016/j.devcel.2008.08.019
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Explant culture data have suggested that the liver and pancreas originate from common progenitors. We used single-cell-lineage tracing in zebrafish to investigate this question in vivo as well as to analyze the hepatic versus pancreatic fate decision. At early somite stages, endodermal cells located at least two cells away from the midline can give rise to both liver and pancreas. In contrast, endodermal cells closer to the midline give rise to pancreas and intestine, but not liver. Loss- and gain-of-function analyses show that Bmp2b, expressed in the lateral plate mesoderm, signals through Alk8 to induce endodermal cells to become liver. When Bmp2b was overexpressed, medially located endodermal cells, fated to become pancreas and intestine, contributed to the liver. These data provide in vivo evidence for the existence of bipotential hepatopancreatic progenitors and indicate that their fate is regulated by the medio-lateral patterning of the endodermal sheet, a process controlled by Bmp2b.
引用
收藏
页码:738 / 748
页数:11
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