Time before anti-Toxoplasma IgG seroconversion detection by 7 commercial assays in French pregnant women

We assessed the ability to early detect a toxoplasmic seroconversion between 1 immunoblot (LDBIO II (R)) and 6 automated assays (TGS TA (R), Architect (R), Vidas II (R), Liaison II (R), Platelia (R), and Elecsys (R)), comparing the time before anti-Toxoplasma gondii IgG detection during infection in pregnant women. From 2007 to 2015, 620 sera of 269 women were included. The median durations before positive IgG detection with Vidas II (R), Liaison II (R), Platelia (R), and Elecsys (R) were significantly longer than Architect (R) with differential times from 11 to 28 days (P < 0.001). This time was significantly shortened by the use of LDBIO (R). resulting in a saving of 13 days (P < 0.001). The detection of a positive rate of IgG with TGS TA (R) was as early as Architect (R) (P = 0.105). The ability to early detect a toxoplasmic seroconversion is not equivalent between the assays and has to be considered when selecting the reagents to reduce the time to therapeutic intervention. (C) 2016 Elsevier Inc. All rights reserved.