Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence

被引：15
|
作者：
Heinzerling, Keith G. [1 ]
Gadzhyan, Janette [1 ]
van Oudheusden, Henry [2 ]
Rodriguez, Felipe [2 ]
McCracken, James [3 ]
Shoptaw, Steven [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Family Med, UCLA Ctr Behav & Addict Med, Los Angeles, CA 90095 USA
[2] Behav Hlth Serv Inc, Gardena, CA USA
[3] Univ Calif Los Angeles, UCLA Child & Adolescent Psychiat, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
来源：
JOURNAL OF ADOLESCENT HEALTH | 2013年 / 52卷 / 04期
关键词：
Methamphetamine; Adolescents; Female; Bupropion; Clinical trial; DEPENDENCE; YOUTH;
D O I：
10.1016/j.jadohealth.2012.10.275
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Purpose: To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. Methods: Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. Results: Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo (p = .043) and males (p = .005) respectively. Conclusions: Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes. (C) 2013 Society for Adolescent Health and Medicine. All rights reserved.
引用
收藏
页码：502 / 505
页数：4
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