Inhibition of complement C1s by sutimlimab (SUT) in patients with cold agglutinin disease (CAD): results on efficacy and safety from the randomized, placebo-controlled phase 3 CADENZA study (NCT03347422)

被引：0

作者：

Roeth, A. ^{[1
]}

Berentsen, S. ^{[2
]}

Barcellini, W. ^{[3
]}

D'Sa, S. ^{[4
]}

Jilma, B. ^{[5
]}

Michel, M. ^{[6
]}

Weitz, I. C. ^{[7
]}

Yamaguchi, M. ^{[8
]}

Nishimura, J. -i ^{[9
]}

Vos, J. M. ^{[10
,11
]}

Storek, M. ^{[12
]}

Wong, N. W. ^{[12
]}

Patel, P. ^{[12
]}

Jiang, X. ^{[12
]}

Vagge, D. ^{[13
]}

Wardecki, M. ^{[14
]}

Shafer, F. ^{[12
]}

Lee, M. ^{[12
]}

Broome, C. M. ^{[15
]}

机构：

[1] Univ Hosp Essen, Dept Hematol & Stem Cell Transplantat, West German Canc Ctr, Essen, Germany

[2] Haugesund Hosp, Dept Res & Innovat, Haugesund, Norway

[3] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[4] Univ Coll London Hosp NHS Fdn Trust, UCLH Ctr Waldenstroms Macroglobulinemia & Related, London, England

[5] Med Univ Vienna, Dept Clin Pharmacol, Vienna, Austria

[6] UPEC, Henri Mondor Univ Hosp, Assistance Publ Hop Paris, Creteil, France

[7] USC, Keck Sch Med, Jane Anne Nohl Div Hematol, Dept Med, Los Angeles, CA USA

[8] Ishikawa Prefectural Cent Hosp, Dept Hematol, Kanazawa, Japan

[9] Osaka Univ, Osaka, Japan

[10] Amsterdam UMC, Amsterdam, Netherlands

[11] Sanquin, Dept Hematol, Amsterdam, Netherlands

[12] Sanofi, Cambridge, England

[13] IQVIA, Bangalore, Karnataka, India

[14] Sanofi, Warsaw, Poland

[15] MedStar Georgetown Univ Hosp, Div Hematol, Washington, DC USA

来源：

ONCOLOGY RESEARCH AND TREATMENT | 2022年 / 45卷 / SUPPL 2期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

V575

引用

页码：172 / 173

页数：2

共 50 条

[1] Sustained Complement C1s Inhibition with Sutimlimab in Patients with Cold Agglutinin Disease Results in Continued Efficacy during Part B of the Randomized Placebo-Controlled Phase 3 Cadenza Study (NCT03347422)
Roeth, Alexander
Berentsen, Sigbjorn
Barcellini, Wilma
D'Sa, Shirley
Jilma, Bernd
Michel, Marc
Weitz, Ilene C.
Yamaguchi, Masaki
Nishimura, Jun-ichi
Vos, Josephine M., I
Cid, Joan
Storek, Michael
Wong, Nancy
Yoo, Ronnie
Wang, Jennifer
Vagge, Deepthi
Wardecki, Marek
Shafer, Frank
Lee, Michelle
Broome, Catherine M.
[J]. BLOOD, 2022, 140 : 2825 - 2827
[2] Sustained complement C1s inhibition with sutimlimab in patients with cold agglutinin disease results in continued efficacy during part B of the randomized placebo-controlled phase 3 CADENZA study (NCT03347422)
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[J]. IMMUNOBIOLOGY, 2023, 228 (05) : 10 - 10
[3] Sustained complement C1s inhibition with sutimlimab in patients with cold agglutinin disease results in continued efficacy during part B of the randomized placebo-controlled phase 3 CADENZA study (NCT03347422)
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[J]. ONCOLOGY RESEARCH AND TREATMENT, 2023, 46 : 120 - 120
[4] C1s-targeted inhibition of classical complement pathway by sutimlimab in cold agglutinin disease (CAD): Efficacy and safety results from the randomized, placebo (PBO)-controlled phase 3 CADENZA study
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[J]. ECLINICALMEDICINE, 2024, 74
[10] Inhibition of Complement Cis By Suti limab in Patients h Cold Agglutinin Disease (CAD): Efficacy and Safety Results om the Rando ized, Placebo-Controlled Phase 3 CADENZA Study
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