Isoprenoid biosynthesis via the methylerythritol phosphate pathway:: accumulation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate in a gcpE deficient mutant of Escheriehia coli

被引：22
|
作者：
Seemann, M
Campos, N
Rodríguez-Concepción, M
Hoeffler, JF
Grosdemange-Billiard, C
Boronat, A
Rohmer, M
机构：
[1] Univ Strasbourg, CNRS, Inst Le Bel, F-67070 Strasbourg, France
[2] Univ Barcelona, Fac Quim, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 05期
关键词：
biosynthesis; 2-C-methyl-D-erythritol; 4-phosphate; 2,4-cyclodiphosphate; gcpE; isoprenoids;
D O I：
10.1016/S0040-4039(01)02269-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the bacterium Escherichia coli. gcpE is an essential gene in the methylerythritol phosphate pathway for isoprenoid biosynthesis. Incubation of [1-H-3]methylerythritol with an E. coli mutant defective in the gcpE gene resulted in the accumulation of [1-H-3]methylerythritol 2,4-cyclodiphosphate. This suggests that the GCPE protein is involved in the further conversion of methylerythritol cyclodiphosphate into isoprenoids. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：775 / 778
页数：4
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