Heme Polymerization Inhibitory Activities of Xanthone from G. parvifolia (Miq) Miq Stem Bark as an Antimalarial Agent

被引：0

作者：

Syamsudin ^{[1
]}

Supargiyono ^{[2
]}

Wahyuono, Subagus ^{[3
]}

Simanjuntak, Partomuan ^{[4
]}

Mustofa ^{[5
]}

机构：

[1] Pancasila Univ, Fac Pharm, Dept Pharmacol, S Jakarta, Indonesia

[2] Gadjah Mada Univ, Dept Parasitol, Fac Med, Yogyakarta, Indonesia

[3] Gadjah Mada Univ, Dept Biol Pharm, Fac Pharm, Yogyakarta, Indonesia

[4] Indonesian Inst Sci, Biotechnol Res Ctr, Cibinong 16911, Indonesia

[5] Gadjah Mada Univ, Dept Pharmacol, Fac Med, Yogyakarta, Indonesia

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 03期

关键词：

G. parvifolia (Miq)Miq bark; Xanthone; Antimalaria; Heme polymerization;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study had been conducted to isolate, to identify and to test heme polymerization inhibitory activities of G. parvifolia (Miq)Miq stem bark active compounds with antimalarial properties. UV, IR, RMI 1D (H-1 NMR and C-13 NMR) and RMI 2D (COSY, HMQC and HMBC) and mass spectra were used for identification. Heme polymerization inhibitory activity assay was conducted in vitro by measuring beta-hematin formation using ELISA reader. The study revealed that the active isolates derived from xanthone compounds, 1,3,6-trihydroxy-2-(3-methylbut-2-enyl)-7-methoxy-8-(3-methylbut-2-enyl)xanthen-9-on. HPIA assay showed that the compounds acted by inhibiting weak heme polymerization activities.

引用

页码：1311 / 1314

页数：4