Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis

被引：44

作者：

Stubbs, Brendon ^{[1
]}

Gardner-Sood, Poonam ^{[2
]}

Smith, Shubulade ^{[3
,4
]}

Ismail, Khalida ^{[3
,5
]}

Greenwood, Kathryn ^{[6
,7
]}

Farmer, Ross ^{[1
]}

Gaughran, Fiona ^{[8
,9
,10
]}

机构：

[1] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[4] South London & Maudsley NHS Fdn Trust, London, England

[5] Kings Coll Hosp London, NHS Fdn Trust, London SE5 8RX, England

[6] Univ Sussex, Sch Psychol, Brighton, E Sussex, England

[7] Sussex Partnership NHS Fdn Trust, Early Intervent Psychosis Serv, Worthing, W Sussex, England

[8] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England

[9] Inst Psychiat Psychol & Neurosci, London, England

[10] BRC Nucleus, Biomed Res Ctr, London, England

来源：

SCHIZOPHRENIA RESEARCH | 2015年 / 168卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

Psychosis; Inflammation; C-reactive protein; Sedentary behaviour; Schizophrenia; Cardiovascular disease; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SCHIZOPHRENIA; INDIVIDUALS;

D O I：

10.1016/j.schres.2015.07.003

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Psychosis is associated with elevated inflammatory markers including C-reactive protein (CRP), a marker of cardiovascular disease (CVD) risk. Using a cross sectional design, 250 participants with established psychosis (48.2 years (SD 10.2), 39.2% female) were classified as having normal (<5.0 mg/mu l, N = 159) or high CRP levels (>5.0 mg/mu l, N = 91). Regression analysis demonstrated that higher sedentary behaviour was associated with elevated CRP levels (beta = .155, p = .01) after adjustment for confounding variables. Female gender (mu = .229, p = .001), waist circumference (beta = .205, p = .003) and non-white ethnicity (mu = .181, p = .005) were also associated with elevated CRP. Sedentary behaviour is modifiable and increasing physical activity may reduce CRP levels. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：461 / 464

页数：4

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