Synthesis of New Biologically Active Polymer Bioconjugates Based on Lupane Mlylamides

Betulonic and 2-hydroxyiminobetulonic acids were synthesized based on betulin triterpenoid, which can readily be isolated from birch (Betula) bark. Allylamides of betulonic and 2-hydroxyiminobetuionic acids were prepared by the reaction of the corresponding acids with allylamine in the presence of oxalyl chloride and triethylamine. It was established that the obtained allylamides copolymerize at low rates with acrylonitrile and N-vinylpyrrolidone in the presence of radical initiators to produce random copolymers. The resulting copolymers exhibit the cytotoxic activity against MS cultures and are promising for developing new bioactive polymer bioconjugates.