Chiral Separation of Basic Compounds on Sulfated β-Cyclodextrin-Coated Zirconia Monolith by Capillary Electrochromatography

被引：12

作者：

Hong, Jong-Seong ^{[1
]}

Park, Jung Hag ^{[1
]}

机构：

[1] Yeungnam Univ, Dept Chem, Kyongsan 712749, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2013年 / 34卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Chiral separation; Capillary electrochromatography; Zirconia monolith; Sulfated beta-cyclodextrin; 2,4-DINITROPHENYL AMINO-ACIDS; CARBON-CLAD ZIRCONIA; STATIONARY PHASES; ELECTROMIGRATION TECHNIQUES; ENANTIOMERIC SEPARATIONS; LIQUID-CHROMATOGRAPHY; IMMOBILIZED ZIRCONIA; QUININE CARBAMATE; CONTINUOUS BEDS; PERFORMANCE;

D O I：

10.5012/bkcs.2013.34.6.1809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sulfated beta-cyclodextrin (SCD)-coated zirconia monolith was used as the chiral stationary phase in capillary electrochromatography for enantiomeric separation of basic chiral compounds. SCD adsorbed on the zirconia surface provided a stable chiral stationary phase in reversed-phase eluents. Retention, chiral selectivity and resolution of a set of six basic chiral compounds were measured in eluents of varying pH, composition of methanol and buffer. Optimum mobile phase condition for the separation of the compounds was found to be methanol content of 30%, buffer concentration of 30 mM and pH of 4.0.

引用

页码：1809 / 1813

页数：5

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