ApoM Suppresses TNF-α-Induced Expression of ICAM-1 and VCAM-1 Through Inhibiting the Activity of NF-κB

被引：22

作者：

Gao, Ji-Juan ^{[1
]}

Hu, Yan-Wei ^{[1
]}

Wang, Yan-Chao ^{[1
]}

Sha, Yan-Hua ^{[1
]}

Ma, Xin ^{[2
]}

Li, Shu-Fen ^{[1
]}

Zhao, Jia-Yi ^{[1
]}

Lu, Jing-Bo ^{[3
]}

Huang, Chuan ^{[1
]}

Zhao, Jing-Jing ^{[1
]}

Zheng, Lei ^{[1
]}

Wang, Qian ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Lab Med Ctr, Guangzhou 510515, Guangdong, Peoples R China

[2] Southern Med Univ, Nanfang Hosp, Dept Anesthesiol, Guangzhou 510515, Guangdong, Peoples R China

[3] Southern Med Univ, Nanfang Hosp, Dept Vasc Surg, Guangzhou 510515, Guangdong, Peoples R China

来源：

DNA AND CELL BIOLOGY | 2015年 / 34卷 / 08期

关键词：

CELL-ADHESION MOLECULE-1; TUMOR-NECROSIS-FACTOR; APOLIPOPROTEIN-M; VASCULAR INFLAMMATION; ACTIVATION; PHOSPHORYLATION; PROTEIN; ATHEROSCLEROSIS; NF-KAPPA-B1; METABOLISM;

D O I：

10.1089/dna.2015.2892

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To explore the anti-inflammatory effect of apolipoprotein M (apoM) on regulation of tumor necrosis factor- (TNF-)-induced expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and further investigate the molecular mechanism of apoM in this process. We found that TNF- could decrease expression of apoM and inhibitor of NF-B- (IB) in HepG2 cells. Overexpression of apoM caused a significant decrease of ICAM-1 and VCAM-1 expression, while it caused a significant increase of IB expression in HepG2 cells. Furthermore, the treatment with TNF- could increase ICAM-1 and VCAM-1 expression, decrease IB protein expression, and increase nuclear factor-B (NF-B) activity, and these effects were markedly enhanced by small interfering RNA (siRNA)-mediated silencing of apoM in HepG2 cells. Our findings demonstrated that apoM suppressed TNF--induced expression of ICAM-1 and VCAM-1 through inhibiting the activity of NF-kappa B.

引用

页码：550 / 556

页数：7

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