Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy

被引：50
|
作者：
Russo, P. [1 ]
Del Bufalo, A. [1 ,2 ]
Cesario, A. [1 ,2 ]
机构：
[1] IRCCS San Raffaele Pisana, Lab Syst Approaches & Non Communicable Dis, I-00166 Rome, Italy
[2] Catholic Univ, I-00168 Rome, Italy
来源：
CURRENT MEDICINAL CHEMISTRY | 2012年 / 19卷 / 31期
关键词：
Cell death; clinical trials; DNA topoisomerases; DNA topoisomerases poisoning; drug discovery and development; flavonoids; phenoxodiol; systems Biology; PHENOXODIOL-INDUCED APOPTOSIS; PROSTATE-CANCER; (-)-EPIGALLOCATECHIN-3-GALLATE EGCG; MOLECULAR TARGETS; PROTEIN-KINASE; CELL-DEATH; PHASE-I; ANTICANCER; INHIBITION; CARCINOMA;
D O I：
10.2174/092986712803833272
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Flavonoids, secondary metabolites ubiquitously produced in the plant kingdom, are low molecular weight polyphenolic molecules. They are characterized by variable chemical structures and show a vast array of biological activities (i.e... antiviral, anti-inflammatory, antitumor, antimicrobial, estrogenic, antiestrogenic, antioxidant, mutagenic and antimutagenic) targeting different pathways. Some of these compounds such as Genistein, Daidzein or its synthetic derivative Phenoxodiol as well as Luteolin and Quercetin are able to inhibit DNA topoisomerases. This review discusses that Flavonoids targeting DNA topoisomerases may lead to novel drug development with anticancer potential.
引用
收藏
页码：5287 / 5293
页数：7
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