The Thermal Amidation of Carboxylic Acids Revisited

被引：98
|
作者：
Goossen, Lukas J. [1 ]
Ohlmann, Dominik M. [1 ]
Lange, Paul P. [1 ]
机构：
[1] Tech Univ Kaiserslautern, Fachbereich Chem, D-67663 Kaiserslautern, Germany
来源：
SYNTHESIS-STUTTGART | 2009年 / 01期
关键词：
amides; amines; condensation; molecular sieves; CONVENIENT SYNTHESIS; PEPTIDE-SYNTHESIS; AMIDES; DERIVATIVES; CONVERSION; CARBOXAMIDES; AMINES; ACTIVATION; REAGENTS; CATALYST;
D O I：
10.1055/s-0028-1083277
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Factors affecting the thermal condensation of carboxylic acids with amines have been investigated, and an effective protocol for this waste-minimized, environmentally benign transformation has been identified. Fourteen examples demonstrate the applicability of this procedure to aliphatic, aromatic and heteroaromatic carboxylic acids and primary and secondary aliphatic as well as aromatic amines. The approach leads to the corresponding amides in good yields.
引用
收藏
页码：160 / 164
页数：5
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