An Efficient Method for Sterically Demanding Suzuki-Miyaura Coupling Reactions

被引：100
|
作者：
Zhao, Qing [1 ]
Li, Chengxi [1 ]
Senanayake, Chris H. [2 ]
Tang, Wenjun [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Beijing 100864, Peoples R China
[2] Boehringer Ingelheim Pharmaceut Inc, Chem Dev, Ridgefield, CT 06877 USA
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 07期
关键词：
biaryls; cross-coupling; homogeneous catalysis; palladium; steric hindrance; ORTHO-SUBSTITUTED BIARYLS; HETEROCYCLIC CARBENE COMPLEXES; HINDERED ARYL CHLORIDES; GENERAL-METHOD; CATALYST; LIGAND; NHC; RUTHENOCENYLPHOSPHINE; HALIDES; BINOL;
D O I：
10.1002/chem.201203898
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient method for sterically demanding Suzuki-Miyaura coupling reactions has been developed with two catalysts, Pd/BI-DIME (see scheme) and Pd/phenanthrene-based ligand. The Pd/BI-DIME catalyst facilitates the syntheses of extremely hindered biaryls bearing ortho-isopropyl substituents. The other catalyst is efficient for the synthesis of functionalized tetra-ortho- substituted biaryls at low catalyst loadings. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2261 / 2265
页数：5
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