Malignant uveal melanoma with metastatic recurrence to the pancreas: A case report

Metastatic pancreatic cancers are uncommon. The most common primary origins are renal, lung, breast, and colon cancer, with sarcoma and melanoma observed less commonly. Distinguishing a primary pancreatic cancer from a metastasis can be difficult based on various non-invasive imaging studies but is crucial to assure appropriate management. We reported a rare case of malignant uveal melanoma (UM) with metastatic recurrence to pancreas diagnosed by endoscopic ultrasound-guided (EUS) fine-needle aspiration (FNA). Under best supportive care, the patient eventually died of disease progression with multiple liver and brain metastases. Prognosis remains poor for patients with metastatic UM owing to no significantly effective treatment. It is important for clinicians to be aware of the possibility of malignant UM metastasizing to intra-abdominal organs even after primary resection.