Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance

被引:14
|
作者
Kishima, Marina Okuyama [1 ]
Coral de Oliveira, Carlos Eduardo [2 ]
Banin-Hirata, Bruna Karina [2 ]
Losi-Guembarovski, Roberta [2 ]
de Oliveira, Karen Brajao [3 ]
Amarante, Marla Karine [2 ]
Ehara Watanabe, Andmaria Angelica [2 ]
机构
[1] Univ Estadual Londrina, Dept Pathol Clin Anal & Toxicol, Univ Hosp Londrina, Lab Human Pathol,Hlth Sci Ctr, BR-86038350 Londrina, PR, Brazil
[2] Univ Estadual Londrina, Lab Study & Applicat DNA Polymorphisms & Immunol, Dept Pathol Sci, Ctr Biol Sci, BR-86057970 Londrina, PR, Brazil
[3] Univ Estadual Londrina, Lab Mol Genet & Immunol, Dept Pathol Sci, Ctr Biol Sci, BR-86057970 Londrina, PR, Brazil
关键词
CHEMOKINE RECEPTOR CXCR4; LYMPH-NODE METASTASIS; FUNCTIONAL EXPRESSION; CELLS; ACTIVATION; CARCINOMA; SUBTYPES; CXCL12; AXIS;
D O I
10.1155/2015/891020
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most studied role for CXCL12 chemokine and its receptor CXCR4 in breast cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for breast cancer cell migration to other sites such as lung, bone, and lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 is being considered a prognostic marker in breast cancer. Within this context, this review summarizes established studies involving expression of CXCR4 on breast cancer, focusing on its clinical significance.
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页数:6
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