Diagnostic accuracy of serum protein electrophoresis and free light chain measurements for monoclonal gammopathies

被引:4
|
作者
Pena, Camila [1 ]
Ortiz, Manuela [2 ]
Voisin, Javier [3 ]
Peralta, Alexis [2 ]
Balboa, Viviana [2 ]
Delgado, Florencia [4 ]
机构
[1] Hosp Salvador, Secc Hematol, Santiago, Chile
[2] Hosp Salvador, Lab Reumatol Inmunol, Santiago, Chile
[3] Hosp Salvador, Serv Med, Santiago, Chile
[4] Binding Site, Buenos Aires, DF, Argentina
关键词
Diagnosis; Multiple Myeloma; Paraproteinemias; URINE; ASSAYS;
D O I
10.4067/s0034-98872018000100064
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis. Aim: To evaluate the sensibility of a simple screening panel (SPE + FLC). Material and Methods: We analyzed 191 consecutive serum samples of patients with a suspected monoclonal gammopathy (MG). Results: Seventy five patients were diagnosed with MG. The sensitivity and specificity of the combination of SPE + FLC for the diagnosis of monoclonal gammopathy were 95% (95% confidence intervals 89-99) and 99% (95% confidence intervals 96-100), respectively. Conclusions: We were able to validate the international recommendations on the diagnostic accuracy of this simple combination of two tests in serum for monoclonal gammopathy.
引用
收藏
页码:64 / 67
页数:4
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