Analysis of impurities in vertilmicin sulfate by liquid chromatography ion-trap mass spectrometry

被引：8

作者：

Yuan, Yao-zuo ^{[1
,3
]}

Zhang, Mei ^{[1
]}

Fan, Xia-Lei ^{[1
]}

Hu, Chang-qin ^{[2
]}

Jin, Shao-hong ^{[2
]}

Van Schepdael, Ann ^{[3
]}

Hoogmartens, Jos ^{[3
]}

Adams, Erwin ^{[3
]}

机构：

[1] JiangSu Prov Inst Food & Drug Control, Nanjing 210008, Jiangsu, Peoples R China

[2] Natl Inst Food & Drug Control, Being 100050, Peoples R China

[3] Katholieke Univ Leuven, Fac Pharmaceut Sci, Lab Pharmaceut Anal, B-3000 Louvain, Belgium

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2013年 / 80卷

关键词：

Vertilmicin sulfate; Aminoglycoside antibioticsl; LC/MS; Impurity;

D O I：

10.1016/j.jpba.2013.02.026

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The characterization of impurities present in vertilmicin by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed phase (RP)-LC method using a C-18 column resistant to basic pH with an alkaline (pH 11) aqueous mobile phase was developed and coupled to MS with an electrospray ionization (ESI) source in the positive ion mode which provides MSn capability. In total, 18 impurities were detected in a commercial sample. Eleven impurities described in this work were newly identified. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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