Potential role of nitric oxide and endothelin in the pathogenesis of glaucoma

被引：108

作者：

Haefliger, IO ^{[1
]}

Dettmann, E ^{[1
]}

Liu, R ^{[1
]}

Meyer, P ^{[1
]}

Prünte, C ^{[1
]}

Messerli, J ^{[1
]}

Flammer, J ^{[1
]}

机构：

[1] Univ Basel, Eye Clin, Lab Ocular Pharmacol & Physiol, CH-4012 Basel, Switzerland

来源：

SURVEY OF OPHTHALMOLOGY | 1999年 / 43卷

关键词：

choroid; endothelin; endothelium-derived contracting factor; endothelium-derived relaxing factor; nitric oxide; nitric oxide synthase; normal-tension glaucoma; retina; trabecular meshwork; vasospasm;

D O I：

10.1016/S0039-6257(99)00026-0

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Glaucoma is an optic nerve head neuropathy in which retinal ganglion cells are lost. A clear association exists between glaucoma and different risk factors, such as high intraocular pressure (IOP) or blood-flow dysregulation. Nitric oxide (NO) and endothelin, two recently identified cellular mediators, appear to be involved in the regulation of IOP as well as in the modulation of ocular blood flow. To some extent, NO is also involved in apoptosis, a mechanism of cell death that can lead to retinal ganglion cell loss in glaucoma. This article provides a short and simplified overview of the biochemistry of NO and endothelin and highlights the potential role of these two mediators in certain important aspects related to the pathogenesis of glaucoma. (C) 1999 by Elsevier Science Inc. All rights reserved.

引用

页码：S51 / S58

页数：8

共 50 条

[1] The potential role of endothelin in glaucoma
Chauhan, B.
ACTA OPHTHALMOLOGICA, 2013, 91
[2] The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients
Tomic, Monika
Galesic, Kresimir
Morovic-Vergles, Jadranka
Romic, Zeljko
Mikulic, Ivanka
COLLEGIUM ANTROPOLOGICUM, 2008, 32 (01) : 93 - 98
[3] Endothelin and its potential role in glaucoma
Chauhan, Balwantray C.
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, 2008, 43 (03): : 356 - 360
[4] Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension
Ni, ZM
Bemanian, S
Kivlighn, SD
Vaziri, ND
KIDNEY INTERNATIONAL, 1998, 54 (01) : 188 - 192
[5] Endothelin-1 and Nitric Oxide Levels in Patients with Glaucoma
Ghanem, Asaad A.
Elewa, Ahmed M.
Arafa, Lmiaa F.
OPHTHALMIC RESEARCH, 2011, 46 (02) : 98 - 102
[6] Potential role of endothelin and nitric oxide in physiology and pathophysiology of the lower urinary tract
Mumtaz, FH
Khan, MA
Sullivan, ME
Thompson, CS
Mikhailidis, DP
Morgan, RJ
Dashwood, MR
ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH, 1999, 7 (01): : 1 - 9
[7] Endothelin and Its Suspected Role in the Pathogenesis and Possible Treatment of Glaucoma
Shoshani, Yochai Z.
Harris, Alon
Shoja, Mohammadali M.
Rusia, Deepam
Siesky, Brent
Arieli, Yoel
Wirostko, Barbara
CURRENT EYE RESEARCH, 2012, 37 (01) : 1 - 11
[8] Role of endothelin and nitric oxide in the pathogenesis of arterial hypertension in autosomal dominant polycystic kidney disease
Merta, M
Reiterová, J
Rysavá, R
Tesar, V
Závada, J
Jáchymová, M
Zima, T
PHYSIOLOGICAL RESEARCH, 2003, 52 (04) : 433 - 437
[9] Role of nitric oxide in the pathogenesis of atherosclerosis
Cooke, JP
JOURNAL OF PHYSIOLOGY-LONDON, 1998, 506P : 20S - 20S
[10] Nitric oxide, endothelin and nephron transport: Potential interactions
Plato, CF
Garvin, JL
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1999, 26 (03) : 262 - 268

← 1 2 3 4 5 →