Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei

被引：20
|
作者：
Guo, YQ
Xu, J
Li, YS
Watanabe, R
Oshima, Y
Yamakuni, T
Ohizumi, Y [1 ]
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol Mol Biol, Sendai, Miyagi 9808578, Japan
[2] Shenyang Pharmaceut Univ, Res Dept Nat Med, Shenyang 110016, Peoples R China
[3] Tohoku Univ, Grad Sch Life Sci, Bioorgan Chem Lab, Sendai, Miyagi 9818555, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 01期
关键词：
Valeriana fauriei; iridoid glycoside; sesquiterpenoid; nerve growth factor (NGF)-potentiating activity;
D O I：
10.1248/cpb.54.123
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new iridoid glycoside, 10-isovaleryl kanokoside C (1), and a new sesquiterpene (2) together with two known compounds (3, 4) were isolated from the rhizomes and roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.
引用
收藏
页码：123 / 125
页数：3
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