Vitamin D2 or vitamin D3?

被引：12

作者：

Mistretta, V. I. ^{[1
]}

Delanaye, P. ^{[2
]}

Chapelle, J. -P. ^{[1
]}

Souberbielle, J. -C. ^{[3
]}

Cavalier, E. ^{[1
]}

机构：

[1] Univ Liege, CHU Liege, Serv Chim Med, B-4000 Liege, Belgium

[2] Univ Liege, CHU Liege, Serv Nephrol, B-4000 Liege, Belgium

[3] Univ Paris 05, Hop Necker, AP HP,Serv Explorat Fonct, INSERM,U845, Paris, France

来源：

REVUE DE MEDECINE INTERNE | 2008年 / 29卷 / 10期

关键词：

Vitamin D2; Vitamin D3; Ergocalciferol; Cholecalciferol; Efficiency;

D O I：

10.1016/j.revmed.2008.03.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose. - Nearly one billion people around the world are deficient in vitamin D and need to be supplemented. Vitamin D is available in medicines and fortified foods. It is available in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Key points. - The pharmacopeiae consider these steroid hormones as equivalent and interchangeable. However, several studies have showed that serum level of 25(OH)D is increased more effectively with vitamin D3 than vitamin D2. Vitamin D2 has shorter plasma half-life and a lower affinity for the vitamin D binding protein, the hepatic vitamin D hydroxylase and the vitamin D receptor. Conclusion. - Vitamin D2 should not be regarded anymore as suitable for supplementation or fortification. Currently though, it is still the most used in some countries such as Portugal and Australia. (C) 2008 Elsevier Masson SAS. Tous droits reserves.

引用

页码：815 / 820

页数：6

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