Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

被引:8
|
作者
Vargas-Mendoza, Nancy [1 ]
Angeles-Valencia, Marcelo [1 ]
Madrigal-Santillan, Eduardo Osiris [1 ]
Morales-Martinez, Mauricio [2 ]
Tirado-Lule, Judith Margarita [3 ]
Solano-Urrusquieta, Arturo [4 ]
Madrigal-Bujaidar, Eduardo [5 ]
Alvarez-Gonzalez, Isela [5 ]
Fregoso-Aguilar, Tomas [6 ]
Morales-Gonzalez, Angel [3 ]
Morales-Gonzalez, Jose A. [1 ]
机构
[1] Inst Politecn Nacl, Lab Med Conservac, Escuela Super Med, Mexico City 11340, DF, Mexico
[2] Univ Intercontinental, Nutr, Insurgentes Sur 4303, Mexico City 14420, DF, Mexico
[3] Inst Politecn Nacl, Escuela Super Comp, Ave Juan de Dios Batiz S-N Esquina Miguel Othon, Mexico City 07738, DF, Mexico
[4] Secretaria Def Nacl, Hosp Mil Zona, Perifer Blvd Manuel Avila Camacho S-N, Mexico City 11200, DF, Mexico
[5] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Unidad Profes A Lopez Mateos, Ave Wilfrido Massieu Col, Mexico City 07738, DF, Mexico
[6] Inst Politecn Nacl, Dept Fisiol, Lab Hormonas & Conducta, ENCB Campus Zacatenco, Mexico City 07700, DF, Mexico
关键词
exercise training; muscle; myofibers; myocardium; silymarin; ISCHEMIA-REPERFUSION INJURY; SKELETAL-MUSCLE; MOLECULAR-MECHANISMS; SATELLITE CELLS; FIBER TYPES; VITAMIN-C; DAMAGE; SIZE; ANTIOXIDANTS; ADAPTATION;
D O I
10.3390/ijms21207724
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
(1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/cardiac histological changes, bodyweight, and food intake in rats subjected to 60 min of regular exercise training (RET) five days per week. (2) Methods: Male Wistar rats were subjected to an eight-week RET treadmill program and were previously administered SM and vitamin C. Bodyweight and food consumption were measured and registered. The maximal endurance capacity (MEC) test was performed at weeks one and eight. After the last training session, the animals were sacrificed, and samples of quadriceps/gastrocnemius and cardiac tissue were obtained and process for histological analyzes. (3) Results: SM consumption improved muscle recovery, inflammation, and damaged tissue, and promoted hypertrophy, vascularization, and muscle fiber shape/appearance. MEC increased after eight weeks of RET in all trained groups; moreover, the SM-treated group was enhanced more than the group with vitamin C. There were no significant changes in bodyweight and in food and nutrient consumption along the study. (5) Conclusion: SM supplementation may enhance physical performance, recovery, and muscle hypertrophy during the eight-week RET program.
引用
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页码:1 / 23
页数:23
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