Role of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailand

被引：15
|
作者：
Louisirirotchanakul, S
Beddows, S
Cheingsong, R
Shaffer, N
Mastro, TD
Likanonsakul, S
Wasi, C
Taylor, GP
Weber, JN
机构：
[1] St Marys Hosp, Imperial Coll, Sch Med,Dept Genitourinary Med & Communicable Dis, Jefferiss Res Trust Labs, London W2 1NY, England
[2] HIV AIDS Collaborat, Nonthaburi, Thailand
[3] Ctr Dis Control & Prevent, Atlanta, GA USA
[4] Bamrasnaradura Infect Dis Hosp, Dept Communicable Dis Control, Minist Publ Hlth, Nonthaburi, Thailand
[5] Mahidol Univ, Dept Microbiol, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand
来源：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 1999年 / 21卷 / 04期
基金：
英国惠康基金;
关键词：
HIV-1; antibody; vertical transmission; binding and neutralizing; subtypes B and E; hemodilution;
D O I：
10.1097/00126334-199908010-00001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The significance of the maternal humoral immune response in relation to vertical transmission of HIV-I was investigated in 123 mothers infected with subtype E from Thailand. Antibody binding titers to HIV-1 env domains (monomeric gp120, the CD4/gp120 binding site [BS], V3 loop, and gp41) and antibody-mediated neutralization of primary and T-cell line-adapted (TCLA) subtypes B and E HIV-1 isolates were investigated. No correlation between maternal anti HIV-1 antibodies at delivery and vertical transmission of HIV-1 subtype E was found. However, a trend to higher titer antibody-mediated cross-neutralization of a heterologous subtype B TCLA isolate, HIV-1(MN), was observed in nontransmitting mothers postpartum. The HIV-1-specific antibody titers in these infected mothers increased significantly from delivery to 6 months postpartum (p < .05), but this was only partially attributable to hemodilution and an additional factor or factors appear to affect humoral immunity to HIV-1 during late pregnancy.
引用
收藏
页码：259 / 265
页数：7
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