Role and regulation of dopamine D1 receptors in the striatum:: implications for the genesis of dyskinesia in Parkinson's disease.

被引：7
|
作者：
Corvol, J. -C.
Girault, J. -A.
Herve, D.
机构：
[1] CHU Pitie Salpetriere, Federat Malad Syst Nerveux, F-75651 Paris 13, France
[2] Inst Fer Moulin, UPMC, INSERM U536, Paris, France
来源：
REVUE NEUROLOGIQUE | 2006年 / 162卷 / 6-7期
关键词：
D1 dopamine receptor; G protein; Parkinson's disease; dyskinesia;
D O I：
10.1016/S0035-3787(06)75066-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
L-dopa treatment of Parkinson's disease is complicated in the long term by the appearance of dyskinesia. Hypersensitivity of D1 dopamine receptor has been suggested to play a role in these delayed adverse effects. Hypersensitivity of dopamine D1 receptor in Parkinson's disease can be accounted for by increased levels of G alpha olf, the stimulatory G protein which couples D I receptor to adenylyl cyclase in the striatum. We here discuss the possible role of D1 receptor signal transduction in the genesis of L-dopa-induced dyskinesia in the light of G alpha olf regulation.
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页码：691 / 702
页数：12
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