Purpose of review To review the most recent literature on anesthesia for in-vitro fertilization. Recent findings Very limited new information has become available in the review period. Propofol seems to be an acceptable option for anesthesia/sedation during in-vitro fertilization but more research is necessary to definitively establish its safety. Remifentanil is also an effective alternative. Summary Presently, propofol and remifentanil seem to be acceptable options for anesthesia for in-vitro fertilization but further research is required.